Mining Dense Patterns from Off Diagonal Protein Contact Maps
نویسندگان
چکیده
منابع مشابه
Mining Dense Patterns from Off Diagonal Protein Contact Maps
The three dimensional structure of proteins is useful to carry out the biophysical and biochemical functions in a cell. Protein contact maps are 2D representations of contacts among the amino acid residues in the folded protein structure. Proteins are biochemical compounds consisting of one or more polypeptides, facilitating a biological function. Many researchers make note of the way secondary...
متن کاملMining Protein Contact Maps
The 3D conformation of a protein may be compactly represented in a symmetrical, square, boolean matrix of pairwise, inter-residue contacts, or “contact map”. The contact map provides a host of useful information about the protein’s structure. In this paper we describe how data mining can be used to extract valuable information from contact maps. For example, clusters of contacts represent certa...
متن کاملMining of protein contact maps for protein fold prediction
Contact maps have been used in ab initio methods for the problem of protein structure prediction problem. Secondary structures and contacts made by the residues are clearly visible in the contact maps where helices are seen as thick bands and the beta sheets are seen as orthogonal to the diagonal. This paper explores the idea of extracting rules from contact maps to represent “protein fold” inf...
متن کاملRecovery of protein structure from contact maps.
BACKGROUND Prediction of a protein's structure from its amino acid sequence is a key issue in molecular biology. While dynamics, performed in the space of two-dimensional contact maps, eases the necessary conformational search, it may also lead to maps that do not correspond to any real three-dimensional structure. To remedy this, an efficient procedure is needed to reconstruct three-dimensiona...
متن کاملAn On/Off Lattice Approach to Protein Structure Prediction from Contact Maps
An important unsolved problem in structural bioinformatics is that of protein structure prediction (PSP), the reconstruction of a biologically plausible three-dimensional structure for a given protein given only its amino acid sequence. The PSP problem is of enormous interest, because the function of proteins is a direct consequence of their three-dimensional structure. Approaches to solve the ...
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ژورنال
عنوان ژورنال: International Journal of Computer Applications
سال: 2012
ISSN: 0975-8887
DOI: 10.5120/7682-0987